South America · Chile

Your Santa Cruz Staycation

Hand-picked hotels in Santa Cruz — ranked by real guest scores, with live Agoda rates and one-tap booking. From boutique hideaways to luxury icons, every stay is curated by Staycation.

Curated stays

8.9/ 10

Average guest score

5-star properties

7 properties · curated by Staycation

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Hotel

Santa Cruz, Chile

Hotel Santa Cruz Plaza

Cava Colchagua Hotel Boutique

Hotel Boutique Vendimia Premium

★★★★

🍳 Free breakfast📶 Free WiFi

Hotel Boutique Grand Cru

Hotel Boutique Vendimia Parador

Hotel Boutique Solaz Bella Vista de Colchagua

★★★

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The Best Santa Cruz Staycation Hotels

Whether you’re planning a weekend staycation in Santa Cruz or a longer escape acrossChile, Staycation curates the finest places to stay — from boutique hideaways and heritage hotels to iconic luxury properties. Every Santa Cruz staycation hotel is ranked by real guest scores, so you can book with confidence.

Rates are powered by Agoda, with live availability and competitive pricing. Pick your dates above to see tonight’s best Santa Cruz staycation deals, or explore other destinations in South America.