Florence (SC) staycation hotels

North America · United States

Your Florence (SC) Staycation

Hand-picked hotels in Florence (SC) — ranked by real guest scores, with live Agoda rates and one-tap booking. From boutique hideaways to luxury icons, every stay is curated by Staycation.

43
Curated stays
7.9/ 10
Average guest score

43 properties · curated by Staycation

Homewood Suites by Hilton FlorenceHotel
Florence (SC), United States
Homewood Suites by Hilton Florence
★★★
🍳 Free breakfast📶 Free WiFi
9.4Exceptional
For your dates
$198 USD
Holiday Inn Express & Suites Florence By IHGHotel
Florence (SC), United States
Holiday Inn Express & Suites Florence By IHG
★★★
🍳 Free breakfast📶 Free WiFi
8.6Excellent
For your dates
$188 USD
TownePlace Suites by Marriott FlorenceHotel
Florence (SC), United States
TownePlace Suites by Marriott Florence
★★★★
🍳 Free breakfast
4.4Good
For your dates
$169 USD
Staybridge Suites Florence - Civic Center By IHGHotel
Florence (SC), United States
Staybridge Suites Florence - Civic Center By IHG
★★★
🍳 Free breakfast📶 Free WiFi
9.7Exceptional
For your dates
$161 USD
Holiday Inn Express & Suites Florence I-95 & I-20 Civic CtrHotel
Florence (SC), United States
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr
★★★
🍳 Free breakfast📶 Free WiFi
9.3Exceptional
For your dates
$157 USD
Home2 Suites by Hilton FlorenceHotel
Florence (SC), United States
Home2 Suites by Hilton Florence
★★★
🍳 Free breakfast📶 Free WiFi
9.5Exceptional
For your dates
$151 USD
Comfort Suites Florence I-95Hotel
Florence (SC), United States
Comfort Suites Florence I-95
★★★
📶 Free WiFi
8.2Excellent
For your dates
$148 USD
Residence Inn by Marriott FlorenceHotel
Florence (SC), United States
Residence Inn by Marriott Florence
★★★
🍳 Free breakfast📶 Free WiFi
9.4Exceptional
For your dates
$148 USD
Fairfield by Marriott Inn & Suites Florence I-20Hotel
Florence (SC), United States
Fairfield by Marriott Inn & Suites Florence I-20
★★★
🍳 Free breakfast
8.7Excellent
For your dates
$144 USD
Hotel Florence, Tapestry Collection by HiltonHotel
Florence (SC), United States
Hotel Florence, Tapestry Collection by Hilton
★★★★
📶 Free WiFi
9.4Exceptional
For your dates
$143 USD
Comfort Inn & Suites Florence Center AreaHotel
Florence (SC), United States
Comfort Inn & Suites Florence Center Area
★★★
📶 Free WiFi
9.0Exceptional
For your dates
$140 USD
Hampton Inn & Suites by Hilton Florence CenterHotel
Florence (SC), United States
Hampton Inn & Suites by Hilton Florence Center
★★★
🍳 Free breakfast📶 Free WiFi
9.0Exceptional
For your dates
$137 USD
Hyatt Place Florence DowntownHotel
Florence (SC), United States
Hyatt Place Florence Downtown
★★★
🍳 Free breakfast
9.3Exceptional
For your dates
$135 USD
Aloft by Marriott FlorenceHotel
Florence (SC), United States
Aloft by Marriott Florence
★★★
8.5Excellent
For your dates
$135 USD
Hampton Inn & Suites Florence-North-I-95Hotel
Florence (SC), United States
Hampton Inn & Suites Florence-North-I-95
★★★
🍳 Free breakfast📶 Free WiFi
8.9Excellent
For your dates
$132 USD
Hilton Garden Inn FlorenceHotel
Florence (SC), United States
Hilton Garden Inn Florence
★★★
📶 Free WiFi
8.5Excellent
For your dates
$131 USD
Courtyard by Marriott FlorenceHotel
Florence (SC), United States
Courtyard by Marriott Florence
★★★
7.1Very Good
For your dates
$124 USD
Tru by Hilton Florence I-95Hotel
Florence (SC), United States
Tru by Hilton Florence I-95
★★★
🍳 Free breakfast📶 Free WiFi
7.2Very Good
For your dates
$122 USD
Park Inn by Radisson Florence, SCHotel
Florence (SC), United States
Park Inn by Radisson Florence, SC
★★★
📶 Free WiFi
8.6Excellent
For your dates
$121 USD
SpringHill Suites by Marriott FlorenceHotel
Florence (SC), United States
SpringHill Suites by Marriott Florence
★★★
🍳 Free breakfast
8.9Excellent
For your dates
$119 USD
Best Western InnHotel
Florence (SC), United States
Best Western Inn
📶 Free WiFi
7.6Very Good
For your dates
$109 USD
Quality Inn & Suites Florence Civic CenterHotel
Florence (SC), United States
Quality Inn & Suites Florence Civic Center
★★★
🍳 Free breakfast📶 Free WiFi
8.4Excellent
For your dates
$108 USD
Spark by Hilton Florence North I-95, SCHotel
Florence (SC), United States
Spark by Hilton Florence North I-95, SC
★★★
🍳 Free breakfast📶 Free WiFi
7.2Very Good
For your dates
$101 USD
La Quinta Inn & Suites by Wyndham FlorenceHotel
Florence (SC), United States
La Quinta Inn & Suites by Wyndham Florence
★★★
8.3Excellent
For your dates
$99 USD
Days Inn by Wyndham Florence Near Civic CenterHotel
Florence (SC), United States
Days Inn by Wyndham Florence Near Civic Center
★★★
🍳 Free breakfast📶 Free WiFi
8.3Excellent
For your dates
$83 USD
Sleep Inn Florence NorthHotel
Florence (SC), United States
Sleep Inn Florence North
★★★
🍳 Free breakfast📶 Free WiFi
8.2Excellent
For your dates
$81 USD
Howard Johnson by Wyndham FlorenceHotel
Florence (SC), United States
Howard Johnson by Wyndham Florence
★★
📶 Free WiFi
8.7Excellent
For your dates
$81 USD
MainStay Suites Florence - DarlingtonHotel
Florence (SC), United States
MainStay Suites Florence - Darlington
★★★
🍳 Free breakfast
5.9Good
For your dates
$80 USD
Affordable Suites FlorenceHotel
Florence (SC), United States
Affordable Suites Florence
★★
📶 Free WiFi
10.0Exceptional
For your dates
$77 USD
Microtel Inn & Suites by Wyndham FlorenceHotel
Florence (SC), United States
Microtel Inn & Suites by Wyndham Florence
★★
🍳 Free breakfast📶 Free WiFi
7.2Very Good
For your dates
$74 USD
Days Inn by Wyndham Florence/I-95 NorthHotel
Florence (SC), United States
Days Inn by Wyndham Florence/I-95 North
★★
📶 Free WiFi
7.3Very Good
For your dates
$69 USD
Super 8 by Wyndham Florence SC I-95 North / Hwy 76Hotel
Florence (SC), United States
Super 8 by Wyndham Florence SC I-95 North / Hwy 76
★★
📶 Free WiFi
6.0Good
For your dates
$68 USD
Red Roof Inn Florence - Civic CenterHotel
Florence (SC), United States
Red Roof Inn Florence - Civic Center
★★
📶 Free WiFi
6.8Good
For your dates
$66 USD
Suburban Studios Florence I-95Hotel
Florence (SC), United States
Suburban Studios Florence I-95
★★
📶 Free WiFi
6.1Good
For your dates
$65 USD
Motel 6 Florence, SCHotel
Florence (SC), United States
Motel 6 Florence, SC
★★
📶 Free WiFi
4.8Good
For your dates
$65 USD
Super 8 By Wyndham FlorenceHotel
Florence (SC), United States
Super 8 By Wyndham Florence
★★
🍳 Free breakfast
7.6Very Good
For your dates
$64 USD
Rodeway Inn Florence DowntownHotel
Florence (SC), United States
Rodeway Inn Florence Downtown
★★
📶 Free WiFi
0.0Good
For your dates
$63 USD
Econo Lodge Florence - DarlingtonHotel
Florence (SC), United States
Econo Lodge Florence - Darlington
★★
📶 Free WiFi
6.4Good
For your dates
$58 USD
Clarion Inn & Suites Florence - DarlingtonHotel
Florence (SC), United States
Clarion Inn & Suites Florence - Darlington
★★★
📶 Free WiFi
5.7Good
For your dates
$57 USD
Florence Inn and SuitesHotel
Florence (SC), United States
Florence Inn and Suites
★★★
📶 Free WiFi
8.3Excellent
For your dates
$56 USD
Studio 6 Florence, SCHotel
Florence (SC), United States
Studio 6 Florence, SC
★★
📶 Free WiFi
6.8Good
For your dates
$56 USD
Hilton Garden Inn Florence North I 95Hotel
Florence (SC), United States
Hilton Garden Inn Florence North I 95
★★★
0.0Good
AVID HOTELS Florence North by IHGHotel
Florence (SC), United States
AVID HOTELS Florence North by IHG
0.0Good

The Best Florence (SC) Staycation Hotels

Whether you’re planning a weekend staycation in Florence (SC) or a longer escape acrossUnited States, Staycation curates the finest places to stay — from boutique hideaways and heritage hotels to iconic luxury properties. Every Florence (SC) staycation hotel is ranked by real guest scores, so you can book with confidence.

Rates are powered by Agoda, with live availability and competitive pricing. Pick your dates above to see tonight’s best Florence (SC) staycation deals, or explore other destinations in North America.